Toxicology in Vitro publishes original research papers and reviews on the application and use of in vitro systems for assessing or predicting the toxic effects of chemicals and elucidating their mechanisms of action. These in vitro techniques include utilizing cell or tissue cultures, isolated cells, tissue slices, subcellular fractions, transgenic cell cultures, and cells from transgenic organisms, as well as in silico modelling. The Journal will focus on investigations that involve the development and validation of new in vitro methods, e.g. for prediction of toxic effects based on traditional and in silico modelling; on the use of methods in high-throughput toxicology and pharmacology; elucidation of mechanisms of toxic action; the application of genomics, transcriptomics and proteomics in toxicology, as well as on comparative studies that characterise the relationship between in vitro and in vivo findings. The Journal strongly encourages the submission of manuscripts that focus on the development of in vitro methods, their practical applications and regulatory use (e.g. in the areas of food components cosmetics, pharmaceuticals, pesticides, and industrial chemicals). Toxicology in Vitro discourages papers that record reporting on toxicological effects from materials, such as plant extracts or herbal medicines, that have not been chemically characterized.
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Scientists correct a mutation in fertilized eggs that causes a severe cardiac disease.
Scientists plan to use in vitro fertilization to preserve a species with only three remaining members in the wild.
John Robertson was known for his contributions to reproductive medicine ethics and for solidifying the scholarly connection between biomedicine and law.
The team that oversaw the first use of mitochondrial replacement therapy that resulted in a live birth has published an account of the procedure.
The country’s fertility regulator has approved the first application to carry out mitochondrial replacement therapy, which uses biological material from two women and one man to create an embryo.
Andrzej Tarkowski’s research laid the groundwork for future advances in cloning, stem cell research, and in vitro fertilization.
Three-Parent IVF Advances
By Anna Azvolinsky | November 30, 2016
Differences in the replicative advantages conferred by some mitochondrial DNA haplotypes have implications for mitochondrial replacement therapy, researchers report.
First MRT Baby Born
By Bob Grant | September 28, 2016
Scientists in Mexico achieved the infant’s conception using mitochondrial replacement therapy.
Review: The End of Sex
By Tanya Lewis | May 13, 2016
Legal expert Henry Greely envisions a world in which advances in biotechnology obviate the need for sexual reproduction as we know it.
By Mary Beth Aberlin | May 1, 2016
Science is messy. So lay it out, warts and all.